Naloxone attenuates self-abusive behavior in developmentally disabled clients.

@article{Sandman1983NaloxoneAS,
  title={Naloxone attenuates self-abusive behavior in developmentally disabled clients.},
  author={Curt A. Sandman and Prasanta Datta and Joseph Barron and F. K. Hoehler and Chris R Williams and James M. Swanson},
  journal={Applied research in mental retardation},
  year={1983},
  volume={4 1},
  pages={5-11}
}
The opiate antagonist naloxone was effective in reducing self-abusive behavior in two mentally retarded clients with an extensive history of such behavior. Three doses of naloxone (0.1, 0.2, 0.4 mg) were compared with a vehicle solution in a double-blind, crossover design. Naloxone greatly attenuated self-abusive episodes in one client and eliminated them entirely in the second client. In addition, use of self-restraining behavior by one client was reduced. The findings suggested that some… CONTINUE READING