Naloxonazine actions in vivo.

  title={Naloxonazine actions in vivo.},
  author={Geoffrey S. F. Ling and Rabi Simantov and Jennifer A. Clark and Gavril W Pasternak},
  journal={European journal of pharmacology},
  volume={129 1-2},
Naloxonazine is a relatively selective mu 1 affinity label in binding studies. Like naloxazone, naloxonazine has proven valuable in vivo in establishing a role for mu 1 sites in specific opiate actions. We now report a detailed characterization of naloxonazine's actions in mice and rats. Naloxonazine antagonized morphine analgesia for greater than 24 h without altering lethality. This prolonged action could not be easily explained by a slow rate of elimination since the terminal elimination… CONTINUE READING

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