Nalmefene for treatment of alcohol dependence

@article{Soyka2010NalmefeneFT,
  title={Nalmefene for treatment of alcohol dependence},
  author={Michael Soyka and Susanne R{\"o}sner},
  journal={Expert Opinion on Investigational Drugs},
  year={2010},
  volume={19},
  pages={1451 - 1459}
}
  • M. Soyka, S. Rösner
  • Published 21 October 2010
  • Medicine, Psychology
  • Expert Opinion on Investigational Drugs
Importance of the field: Alcohol use and dependence are frequent disorders. Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge. Areas covered in this review: The opioidergic system plays a crucial role in mediating the rewarding effects of alcohol, in part by modulating dopaminergic neurotransmission in mesolimbic brain areas. This review will… 
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A patient with diagnosed alcohol use disorder and schizoaffective disorder who received treatment with nalmefene showed decompensation of psychotic symptoms after two doses of medication, consisting of auditory hallucinations, delusions, and ideas of persecution.
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The aim of the present article is to review the basic pharmacological features of naltrexone and its use in the treatment of alcohol dependence.
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The aim of the present article is to review the basic pharmacological features of naltrexone and its use in the treatment of alcohol dependence.
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The major effect of naltrexone is reducing episodic heavy drinking, a pattern often seen in Aboriginal and Torre Strait Islander peoples with alcohol dependence, and possible genetic and epigenetic factors, and practical considerations including once-daily dosing also make nALTrexone an appealing agent in this population.
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Recent animal models used to study drug addiction and the contribution of data generated by these animal models for the clinical treatment of addictive disorders are reviewed.
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