Nalmefene for treatment of alcohol dependence

  title={Nalmefene for treatment of alcohol dependence},
  author={Michael Soyka and Susanne R{\"o}sner},
  journal={Expert Opinion on Investigational Drugs},
  pages={1451 - 1459}
  • M. Soyka, S. Rösner
  • Published 21 October 2010
  • Medicine, Psychology
  • Expert Opinion on Investigational Drugs
Importance of the field: Alcohol use and dependence are frequent disorders. Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge. Areas covered in this review: The opioidergic system plays a crucial role in mediating the rewarding effects of alcohol, in part by modulating dopaminergic neurotransmission in mesolimbic brain areas. This review will… 
Opioid modulators for alcohol dependence
Naltrexone – and to a lesser extent nalmefene – is an agent that modulates opioidergic transmission in the CNS and it shows a limited but well-studied efficacy in treating alcohol dependence.
Pharmakotherapie der Alkoholabhängigkeit
To date, biologically-oriented addiction research has failed to produce a “magic bullet” to improve the prognosis or reduce the risk of relapse in alcohol dependence, but the first evidence-based therapeutic approaches exist.
Efficacy and safety of pregabalin in the treatment of alcohol and benzodiazepine dependence
Monotherapy with pregabalin, within the dosage range of 150 – 600 mg/d, is a promising “novel” option for the safe and efficacious relapse prevention of both AD and BD, however, its efficacy in the acute treatment of AD withdrawal syndrome is still controversial.
Psychotic Decompensation During Nalmefene Treatment in a Patient With Schizoaffective Disorder: A Case Report
A patient with diagnosed alcohol use disorder and schizoaffective disorder who received treatment with nalmefene showed decompensation of psychotic symptoms after two doses of medication, consisting of auditory hallucinations, delusions, and ideas of persecution.
The use of naltrexone in the treatment of alcohol dependence : pharmacological aspects
The aim of the present article is to review the basic pharmacological features of naltrexone and its use in the treatment of alcohol dependence.
Potential medications for the treatment of alcohol use disorder: An evaluation of clinical efficacy and safety.
A number of alternative medications are now being evaluated for treatment of AUD in human studies, and some show good efficacy with side effects that are mild to moderate in intensity; others have mixed or promising results but are awaiting findings from ongoing studies; and still others show poor efficacy, despite promising preliminary results.
[Pharmacological features of naltrexone and its use in the treatment of alcohol dependence].
The aim of the present article is to review the basic pharmacological features of naltrexone and its use in the treatment of alcohol dependence.
Should naltrexone be the first-line medicine to treat alcohol dependence in Aboriginal and Torres Strait Islander populations? An Australian perspective.
The major effect of naltrexone is reducing episodic heavy drinking, a pattern often seen in Aboriginal and Torre Strait Islander peoples with alcohol dependence, and possible genetic and epigenetic factors, and practical considerations including once-daily dosing also make nALTrexone an appealing agent in this population.
Advancing addiction treatment: what can we learn from animal studies?
Recent animal models used to study drug addiction and the contribution of data generated by these animal models for the clinical treatment of addictive disorders are reviewed.


Emerging drugs to treat alcoholism
A review of drugs that have been clinically tested for the treatment of alcohol dependence in clinical trials, pilot trials or which are considered to have a clinical perspective, finding Acamprosate and the opioid antagonist naltrexone have been found to be effective, although data are mixed.
Pharmacotherapy of alcohol dependence: a review of the clinical data.
  • K. Mann
  • Medicine, Psychology
    CNS drugs
  • 2004
Because the biological basis of alcohol dependence appears to be multifactorial, the future of management of alcoholism may be combination therapy, using drugs acting on different neuronal pathways, such as acamprosate and naltrexone.
Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
Naltrexone-induced nausea in patients treated for alcohol dependence: clinical predictors and evidence for opioid-mediated effects.
The hypothesis that recency and intensity of alcohol use are related to opiate antagonist-precipitated nausea is supported and long-term alcohol use may result in alterations in the endogenous opioid system.
Opioids and alcoholism
Advances in the use of naltrexone: an integration of preclinical and clinical findings.
  • S. O'Malley, J. Froehlich
  • Medicine
    Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
  • 2003
The majority of clinical trials supports the hypothesis that naltrexone can reduce the urge to drink, increase the number of days abstinent, and minimize the risk of relapse to heavy drinking, and the amount of alcohol consumed declines during subsequent sessions in the presence of nALTrexone.
Acamprosate supports abstinence, Naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
When the efficacy profiles of the two drugs were compared, acamprosate was found to be more effective in preventing a lapse, whereas naltrexone was better in prevented a lapse from becoming a relapse.
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence.
Naltrexone and acamprosate may ultimately prove to be useful additions to pharmacotherapy for alcoholism by reducing relapse by inhibits the glutamatergic transmitter system involved in both the negative reinforcing effects of alcohol and the conditioned "pseudo-withdrawal" that may be important in cue-induced relapse.
Drugs for relapse prevention of alcoholism: ten years of progress.
Naltrexone vs. Nefazodone for Treatment of Alcohol Dependence: A Placebo-Controlled Trial