Nalmefene Prevents Alcohol‐Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4

@article{Montesinos2017NalmefenePA,
  title={Nalmefene Prevents Alcohol‐Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4},
  author={J. Montesinos and A. Gil and C. Guerri},
  journal={Alcoholism: Clinical and Experimental Research},
  year={2017},
  volume={41},
  pages={1257–1270}
}
BACKGROUND We previously showed that, by activating innate immune receptors Toll-like 4 (TLR4), adolescent intermittent ethanol (EtOH) exposure causes neuroinflammation, myelin damage, and behavioral dysfunctions. Recent findings reveal that clinically used opioid antagonists naltrexone (NT) and naloxone (NX) inhibit opioid-induced TLR4 signaling and that NT, NX, and nalmefene (NF), the 6-methylene derivative of NX, are able to reduce alcohol drinking escalation. METHODS NF (0.1 mg/kg… Expand
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