Nalidixic acid-induced photosensitivity in mice: a model for pseudoporphyria.

  title={Nalidixic acid-induced photosensitivity in mice: a model for pseudoporphyria.},
  author={John T. Keane and Roger Pearson and Frederick D Malkinson},
  journal={The Journal of investigative dermatology},
  volume={82 3},
Porphyria cutanea tarda (PCT)-like photosensitivity eruptions have occurred in patients treated with nalidixic acid, furosemide (Lasix), or tetracycline. An animal model for nalidixic acid photosensitivity was developed in young CF-1 female mice. The hair on the back was plucked from groups of animals that were injected i.p. each day with nalidixic acid or saline. The animals were exposed to black-lamp radiation for 12 h daily for 6 weeks, followed by a 2-week rest period, and then 4 more weeks… CONTINUE READING