Naked Sendai virus vector lacking all of the envelope‐related genes: reduced cytopathogenicity and immunogenicity

@article{Yoshizaki2006NakedSV,
  title={Naked Sendai virus vector lacking all of the envelope‐related genes: reduced cytopathogenicity and immunogenicity},
  author={Mariko Yoshizaki and Takashi Hironaka and Hitoshi Iwasaki and Hiroshi Ban and Yumiko Tokusumi and Akihiro Iida and Yoshiyuki Nagai and Mamoru Hasegawa and Makoto Inoue},
  journal={The Journal of Gene Medicine},
  year={2006},
  volume={8}
}
Sendai virus (SeV) is a new class of cytoplasmic RNA vector that is free from genotoxicity that infects and multiplies in most mammalian cells, and directs high‐level transgene expression. We improved the vector by deleting all of the envelope‐related genes from the SeV genome and thus reducing its immunogenicity. 
Newly‐developed Sendai virus vector for retinal gene transfer: reduction of innate immune response via deletion of all envelope‐related genes
TLDR
A novel rSeV from which all envelope‐related genes were deleted is developed (rSeV/dFdMdHN) and host immune responses following retinal gene transfer are assessed.
RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis
TLDR
This review provides an update on the available literature covering influenza virus vaccines based on RNA replicons and the pros and cons of these vaccine strategies will be discussed and future perspectives disclosed.
Concept and Technology Underlying Sendai Virus (SeV) Vector Development
TLDR
The conceptual novelty of the SeV vector and the technology used to accommodate a foreign gene of interest into the full-length SeV genome are described and the generation of non-transmissible safer vector versions are described.
Generation of a non‐transmissive Borna disease virus vector lacking both matrix and glycoprotein genes
TLDR
Findings indicate that the rBoDV ΔMG‐based BoDV vector may provide an extremely safe virus vector system and could be a novel strategy for investigating the function of M and G proteins and the host range of bornaviruses.
Paramyxovirus-based production of Rift Valley fever virus replicon particles.
TLDR
It is shown that replicon cells infected with a Newcastle disease virus expressing Gn and Gc (NDV-GnGc) were able to produce high levels of NSR particles, and the novel system provides a promising alternative for transfection-based NSR production.
A Respiratory Syncytial Virus Replicon That Is Noncytotoxic and Capable of Long-Term Foreign Gene Expression
TLDR
An RSV replicon is generated that lacks all three of its glycoprotein genes and so cannot cause cell-cell fusion or virus spread, and could be useful for cytoplasmic gene expression in vitro and in vivo and for screening for compounds active against the viral polymerase.
Generation of optimized and urokinase-targeted oncolytic Sendai virus vectors applicable for various human malignancies
TLDR
Detailed utility of the newly designed uPA-targeted oncolytic SeV has significant potential for treating patients bearing urokinase-expressing cancers in clinical settings and indicates a dramatic improvement of antitumor activity.
Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice
TLDR
The results indicate that pulmonary gene transfer using SeV/dFdMdHN warrants further investigation for its possible use in developing safer therapeutics for neonatal lung diseases, including cystic fibrosis.
Persistent and Stable Gene Expression by a Cytoplasmic RNA Replicon Based on a Noncytopathic Variant Sendai Virus*
TLDR
A novel cytoplasmic RNA replicon capable of expressing installed genes stably without chromosome insertion is reported, which is a potentially valuable genetic platform for various biological applications.
Development of an AIDS vaccine using Sendai virus vectors.
TLDR
The potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection is described.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Recombinant Sendai virus vectors deleted in both the matrix and the fusion genes: efficient gene transfer with preferable properties
Sendai virus (SeV) is a new type of cytoplasmic RNA vector, which infects and replicates in most mammalian cells, directs high‐level expression of the genes on its genome and is free from
Sendai virus vectors as an emerging negative‐strand RNA viral vector system
TLDR
The murine parainfluenza virus type I, or Sendai virus (SeV), has emerged as a prototype virus of this vector group, being employed in numerous in vitro as well as animal studies over the last few years.
Sendai virus for gene therapy and vaccination.
TLDR
Data on the use of SeV for gene therapy and vaccination since January 2004 are reviewed and recent improvements in SeV vectorology are discussed.
A Cytoplasmic RNA Vector Derived from Nontransmissible Sendai Virus with Efficient Gene Transfer and Expression
TLDR
A virion from defective cDNA of Sendai virus (SeV) that is capable of self-replication but incapable of transmissible-virion production is recovered and it is suggested that this vector has great potential for use in human gene therapy and vaccine delivery systems.
Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense
TLDR
This work has shown that the recovery of infectious virus from a transfected cDNA of mononegaviruses including Sendai virus, a prototypic paramyxovirus, is opening the possibility of their genetic engineering.
A New Sendai Virus Vector Deficient in the Matrix Gene Does Not Form Virus Particles and Shows Extensive Cell-to-Cell Spreading
TLDR
SeV/ΔM is a novel type of vector with the characteristic features of loss of virus particle formation and gain of cell-to-cell spreading via a mechanism dependent on the activation of the fusion protein.
Efficient propagation of single gene deleted recombinant Sendai virus vectors.
TLDR
Investigation of the propagation procedures required for single gene deleted recombinant SeVV demonstrated modifications of the cell culture medium composition as well as incubation with vitamin E as crucial steps for the enhancement of SevV-DeltaHN, -DeltaF, or -DeltaM viral particle yield.
Budding of Rabies Virus Particles in the Absence of the Spike Glycoprotein
TLDR
It is found that spikeless rhabdovirus particles were released from cells infected with the G-deficient mutant, demonstrating that a viral surface protein is not required to drive the budding process and that G also possesses an intrinsic and independent exocytosis activity.
Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient Interleukin-2 Gene Transfer in Vaccinated Rats
TLDR
The present results show that the recombinant nontransmissible SeV vector provides efficient in vivo gene transfer that induces significant regression of the established brain tumors and suggest that it will be a safe and useful viral vector for the clinical practice of glioma gene therapy.
Complementation between avirulent Newcastle disease virus and a fusion protein gene expressed from a retrovirus vector: requirements for membrane fusion.
TLDR
The cDNA derived from the fusion gene of the virulent AV strain of Newcastle disease virus was expressed in chicken embryo cells by using a retrovirus vector, providing an active cleaved fusion protein required for the spread of infection.
...
1
2
3
...