Naked Mole Rat

@article{Buffenstein2012NakedMR,
  title={Naked Mole Rat},
  author={Rochelle Buffenstein and Thomas J. Park and Martha A. Hanes and James E. Artwohl},
  journal={The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents},
  year={2012},
  pages={1055 - 1074}
}

Learning of nature: The curious case of the naked mole rat

Spontaneous Histologic Lesions of the Adult Naked Mole Rat (Heterocephalus glaber)

TLDR
The NMR’s relative resistance to cancer in spite of development of other degenerative diseases is confirmed and the utility of zoological databases for baseline pathological data on nontraditional animal models is highlighted.

Clocks Ticking in the Dark: A Review of Biological Rhythms in Subterranean African Mole-Rats

TLDR
It is suggested that ambient temperature and rainfall play an important role in the timing of rhythmic behaviour in mole-rats, and that they likely respond directly to these zeitgebers in the field rather than exhibit robust endogenous rhythms.

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology

TLDR
A comprehensive critical review of naked mole-rat biology is provided and four main 'myths' are argued, which would be better described as oversimplifications, which persist solely in the popular press.

Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi)

TLDR
Compared to other rodents species that have been investigated hitherto, the τht was mostly smaller in the lungs of the subterranean species and C. foxi has the highest mass-specific DLo2.

Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.

TLDR
Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in extraordinarily long-lived naked mole-rats, and the nature of these intrinsic pedomorphic features may also contribute to their prolonged youthfulness, longevity, and healthspan.

Suppressed LPS-mediated TLR4 signaling in the plateau zokor (Eospalax baileyi) compared to the bamboo rat (Rhizomys pruinosus) and rat (Rattus norvegicus).

TLDR
It is speculated that suppression of the TLR4 signaling pathway in the plateau zokor is an adaptation to hypoxic tunnels that decreases antigenic risk and maintains immune homeostasis, reducing the innate immunity investment in the spleen.

The exceptional longevity of the naked mole‐rat may be explained by mitochondrial antioxidant defenses

TLDR
The results indicate that differences in matrix ROS detoxification capacity between species may contribute to their divergence in lifespan, and hypothesized that the capacity of mitochondria to consume ROS might distinguish long‐lived species from short-lived species.

Is the Mole Rat Vomeronasal Organ Functional?

TLDR
The vomeronasal organ (VNO) microanatomy in the naked mole rat is described and preliminary observations are made to determine if H. glaber shares its minimal postnatal VNE growth with other African mole rats.

References

SHOWING 1-10 OF 151 REFERENCES

Subterranean mole-rats naturally have an impoverished calciol status, yet synthesize calciol metabolites and calbindins.

TLDR
The natural absence of detectable circulating concentrations of calcidiol and the threefold greater amount of calcitriol to (24R)-hydroxycalcidiol produced indicate that calciol naturally is in short supply, confirming that Bathyergid mole-rats naturally have an impoverishedCalciol status.

Somatosensory organization and behavior in naked mole‐rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain

TLDR
African naked mole‐rats are subterranean rodents that have a robust orienting response to stimulation of unique vibrissa‐like body hairs that are widely spaced over an otherwise hairless skin that provide unique opportunities to discriminate mechanisms related to tactile spatial orientation, vascular regulation, and nociception.

Degenerate hearing and sound localization in naked mole rats (Heterocephalus glaber), with an overview of central auditory structures

TLDR
The fact that subterranean mammals have little use for vision in a lightless environment suggests that naked mole rats represent an extreme case in this relationship and may explain the fact that, unlike surface‐dwelling mammals, they have virtually lost the ability to localize brief sounds.

Naked mole-rats recruit colony mates to food sources

TLDR
Results indicate that naked mole-rats follow each other's (odour) trails to food, and there are intriguing parallels between the foraging recruitment system of H. glaber and those of other social vertebrates and insects.

Features of visual function in the naked mole-rat Heterocephalus glaber

The eyes and visual capacity of the naked mole-rat, Heterocephalus glaber, a subterranean rodent, were evaluated using anatomical, biochemical, and functional assays, and compared to other rodents of

Kidney concentrating ability of a subterranean xeric rodent, the naked mole-rat (Heterocephalus glaber)

TLDR
The naked mole-rat exhibits a moderate kidney concentrating ability and cannot maintain plasma osmolality or body mass with either extreme water stress or salt loading.

Litter Sizes and Mammary Numbers of Naked Mole-Rats: Breaking the One-Half Rule

TLDR
Among mammals generally and rodents particularly mean litter sizes usually are about one-half the number of mammae, and maximum litter sizes approximate mammary numbers, but naked mole-rats are exceptions to both generalizations.

Micro‐ and macrogeographical genetic structure of colonies of naked mole‐rats Heterocephalus glaber

TLDR
Family analysis of a hybrid captive colony of naked mole‐rats with increased levels of genetic variability using multilocus DNA fingerprinting gave results consistent with Mendelian inheritance, and has revealed for the first time that multiple paternity can occur.
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