Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.

@article{Honda2013NaivelikeCO,
  title={Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.},
  author={Arata Honda and Masanori Hatori and Michiko Hirose and Chizumi Honda and Haruna Izu and Kimiko Inoue and Ryutaro Hirasawa and Shogo Matoba and Sumie Togayachi and Hiroyuki Miyoshi and Atsuo Ogura},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 36},
  pages={
          26157-66
        }
}
Although induced pluripotent stem (iPS) cells are indistinguishable from ES cells in their expression of pluripotent markers, their differentiation into targeted cells is often limited. Here, we examined whether the limited capacity of iPS cells to differentiate into neural lineage cells could be mitigated by improving their base-line level of pluripotency, i.e. by converting them into the so-called "naive" state. In this study, we used rabbit iPS and ES cells because of the easy availability… CONTINUE READING

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