Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty.

@article{Murray2003NaiveTC,
  title={Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty.},
  author={John M. Murray and Gilbert R. Kaufmann and Philip D. Hodgkin and Sharon R. Lewin and Anthony D. Kelleher and Miles P. Davenport and John James Zaunders},
  journal={Immunology and cell biology},
  year={2003},
  volume={81 6},
  pages={
          487-95
        }
}
Analysing T-cell receptor excision circle numbers in healthy individuals we find a marked change in the source of naive T cells before and after 20 years of age. The bulk of the naive T cell pool is sustained primarily from thymic output for individuals younger than 20 years of age whereas proliferation within the naive phenotype is dominant for older individuals. Over 90% of phenotypically naive T cells in middle age are not of direct thymic origin. Moreover, this change in source of naive T… CONTINUE READING

From This Paper

Topics from this paper.
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…