Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

@inproceedings{Guo2016NaivePS,
  title={Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass},
  author={Ge Guo and Ferdinand von Meyenn and F{\'a}tima Aparecida dos Santos and Yaoyao Chen and Wolf Reik and Paul Bertone and Austin G. Smith and Jennifer Nichols},
  booktitle={Stem cell reports},
  year={2016}
}
Conventional generation of stem cells from human blastocysts produces a developmentally advanced, or primed, stage of pluripotency. In vitro resetting to a more naive phenotype has been reported. However, whether the reset culture conditions of selective kinase inhibition can enable capture of naive epiblast cells directly from the embryo has not been determined. Here, we show that in these specific conditions individual inner cell mass cells grow into colonies that may then be expanded over… CONTINUE READING
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Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

  • Guo
  • Stem Cell Reports (2016),
  • 2016

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