Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen.

@article{Ise2002NaiveCT,
  title={Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen.},
  author={Wataru Ise and Mamoru Teruji Totsuka and Yoshitaka Sogawa and Akio Ametani and Satoshi Hachimura and Takehito Sato and Yoshihiro Kumagai and Sonoko Habu and Shuichi Kaminogawa},
  journal={Journal of immunology},
  year={2002},
  volume={168 7},
  pages={3242-50}
}
The amount of an Ag used for stimulation affects the type and magnitude of T cell responses. In this study we have investigated the primary response of naive CD4(+) T cells derived from OVA-specific TCR-transgenic mice (OVA23-3) upon stimulation with varying doses of the antigenic peptide, OVA(323-339). IL-4 expression was maximal with 50 nM Ag and… CONTINUE READING