Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.

  title={Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.},
  author={Shinya Ugawa and Yusuke Ishida and Takashi Ueda and Kiyoshi Inoue and Masataka Nagao and Shoichi Shimada},
  journal={Biochemical and biophysical research communications},
  volume={363 1},
We electrophysiologically investigated the effects of nafamostat mesilate (NM: 6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate) and its two metabolites, 6-amidino-2-naphthol (AN) and p-guanidinobenzoic acid (PGBA), on three distinct types of human acid-sensing ion channels (ASICs). Acid-evoked inward currents at a holding potential of -60mV in ASIC1a- and ASIC2a-expressing oocytes were decreased by extracellular application of NM in a concentration-dependent manner with IC(50… CONTINUE READING

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