Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes.

@article{Kuwahara2005NadifloxacinAA,
  title={Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes.},
  author={Keiichi Kuwahara and Toshiki Kitazawa and Hideki Kitagaki and Teruhisa Tsukamoto and Mikio Kikuchi},
  journal={Journal of dermatological science},
  year={2005},
  volume={38 1},
  pages={
          47-55
        }
}
BACKGROUND Acne vulgaris is a chronic inflammatory disease involving colonization of Propionibacterium acnes (P. acnes), activation of neutrophils and lymphocytes. Circumstantial evidence suggests that antigen-independent and -dependent immune responses against P. acnes are involved in the pathogenesis of inflammatory acne. Epidermal keratinocytes are also suggested to be involved in initiation and progression of cutaneous inflammation. Nadifloxacin, a fluorinated quinolone, has potent… CONTINUE READING
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