NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.

@article{Kemmer2001NadNAE,
  title={NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.},
  author={Gabrielle Kemmer and Thomas James Reilly and J Schmidt-Brauns and Gregorio Zlotnik and Bruce Andrew Green and Michael J. Fiske and Martha Herbert and Anita Kraiss and Stefan Schl{\"o}r and Adam Smith and Joachim Reidl},
  journal={Journal of bacteriology},
  year={2001},
  volume={183 13},
  pages={3974-81}
}
Haemophilus influenzae has an absolute requirement for NAD (factor V) because it lacks almost all the biosynthetic enzymes necessary for the de novo synthesis of that cofactor. Factor V can be provided as either nicotinamide adenosine dinucleotide (NAD), nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR) in vitro, but little is known about the source or the mechanism of uptake of these substrates in vivo. As shown by us earlier, at least two gene products are involved in the… CONTINUE READING
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