Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.

@article{Swirnoff1998Nab1AC,
  title={Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain.},
  author={A H Swirnoff and Elizabeth D. Apel and John Svaren and Brad Sevetson and Drazen B. Zimonjic and Nicholas C. Popescu and Jeffrey Milbrandt},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 1},
  pages={
          512-24
        }
}
Nab proteins constitute an evolutionarily conserved family of corepressors that specifically interact with and repress transcription mediated by three members of the NGFI-A (Egr-1, Krox24, zif/268) family of immediate-early gene transcription factors, which includes NGFI-C, Krox20, and Egr3. We explored the mechanism of Nab1 repression and identified structural domains required for Nab1 function. Nab1 does not act by blocking DNA binding or nuclear localization of NGFI-A. In fact, Nab1… CONTINUE READING

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E2F1 and E1a12s have homologous activaition domain regulated by Rb and CBP

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