NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters.

@article{Lee2005NaSi1AS,
  title={NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters.},
  author={Aven Lee and Paul A. Dawson and Daniel Markovich},
  journal={The international journal of biochemistry & cell biology},
  year={2005},
  volume={37 7},
  pages={1350-6}
}
Sulfate (SO(4)2-) is an important anion regulating many metabolic and cellular processes. Maintenance of SO4(2-) homeostasis occurs in the renal proximal tubule via membrane transport proteins. Two SO(4)2- transporters that have been characterized and implicated in regulating serum SO4(2-) levels are: NaSi-1, a Na+-SO(4)2- cotransporter located at the brush border membrane and Sat-1, a SO4(2-)-anion exchanger located on the basolateral membranes of proximal tubular cells. Unlike Sat-1, for… CONTINUE READING

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