Na-K-2Cl cotransport in intestinal epithelial cells. Influence of chloride efflux and F-actin on regulation of cotransporter activity and bumetanide binding.

@article{Matthews1994NaK2ClCI,
  title={Na-K-2Cl cotransport in intestinal epithelial cells. Influence of chloride efflux and F-actin on regulation of cotransporter activity and bumetanide binding.},
  author={Jeffrey B. Matthews and Jason Anthony Smith and Kevin J Tally and Christopher S. Awtrey and H U Nguyen and Jeremy Rich and James L. Madara},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 22},
  pages={15703-9}
}
Although cAMP-dependent epithelial chloride secretion is largely regulated via apical membrane chloride channels, cAMP also remodels basolateral F-actin and activates basolateral Na-K-2Cl cotransport. Whether activation of cotransport is a primary event or secondary to activation of chloride efflux is not established, and the basis for the cytoskeletal dependence is unknown. We studied cotransport in the intestinal line HT29 (which lacks cAMP-regulated chloride efflux) and in its subclone Cl… CONTINUE READING
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