Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca.

@article{Anderson1990NaHEI,
  title={Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca.},
  author={Steven E. Anderson and Elizabeth Murphy and Charles Steenbergen and Robert E. London and Peter Michael Cala},
  journal={The American journal of physiology},
  year={1990},
  volume={259 6 Pt 1},
  pages={C940-8}
}
Historically, increase in cell Na content during ischemic and hypoxic episodes were thought to result from impaired ATP production causing decreased Na(+)-K(+)-ATPase activity. Here we report the results of testing the alternate hypothesis that hypoxia-induced Na uptake is 1) the result of increased entry, as opposed to decreased extrusion 2) via Na-H exchange operating in a pH regulatory capacity and that cell Ca accumulation occurs via Na-Ca exchange secondary to collapse of the Na gradient… CONTINUE READING

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