Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.

@article{Hashiguchi2011NaveCT,
  title={Na{\"i}ve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.},
  author={Masaaki Hashiguchi and Satoshi Hachimura and Akio Ametani and Takehito Sato and Hidefumi Kojima and Yoshihiro Kumagai and Sonoko Habu and Tetsuji Kobata and Shuichi Kaminogawa},
  journal={Immunology letters},
  year={2011},
  volume={141 1},
  pages={109-15}
}
Peyer's patches (PPs) are potential sites where specific mucosal immune responses and oral tolerance are induced. The unique features of these immune responses are thought to occur in micromilieu and are largely affected by antigen-presenting cells (APCs) such as dendritic cells. In this study, we investigated the cytokine profiles induced by the activation of CD4(+) T cells of PPs. PP cells from TCR transgenic mice secreted greater amounts of IL-5 and IL-6 than spleen cells after antigenic… CONTINUE READING

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