Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases

  title={Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases},
  author={Marc Baker Bechmann and Deborah Rotoli and M. Morales and M. Maeso and M. P. Garc{\'i}a and J. {\'A}vila and A. Mobasheri and P. Mart{\'i}n-Vasallo},
  journal={Frontiers in Physiology},
  • Marc Baker Bechmann, Deborah Rotoli, +5 authors P. Martín-Vasallo
  • Published 2016
  • Biology, Medicine
  • Frontiers in Physiology
  • The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na+ affinity respectively and the highest K+ affinity… CONTINUE READING

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