Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases

  title={Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases},
  author={Marc Baker Bechmann and Deborah Rotoli and Manuel Arroyo- Morales and Mar{\'i}a del Carmen Maeso and Mar{\'i}a del Pino Garc{\'i}a and Julio Avila and Ali Mobasheri and Pablo Mart{\'i}n-Vasallo},
  booktitle={Front. Physiol.},
The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na(+) affinity respectively and the highest K(+) affinity… CONTINUE READING
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