Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance.

@article{Nizar2016NasensitiveEI,
  title={Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance.},
  author={Jonathan M Nizar and Wuxing Dong and Robert B McClellan and Mariana Labarca and Yuehan Zhou and Jared J. I. Wong and Donald G Goens and Mingming Zhao and Nona Velarde and Daniel Bernstein and Michael A. Pellizzon and Lisa M. Satlin and Vivek Bhalla},
  journal={American journal of physiology. Renal physiology},
  year={2016},
  volume={310 9},
  pages={
          F812-20
        }
}
The majority of patients with obesity, insulin resistance, and metabolic syndrome have hypertension, but the mechanisms of hypertension are poorly understood. In these patients, impaired sodium excretion is critical for the genesis of Na(+)-sensitive hypertension, and prior studies have proposed a role for the epithelial Na(+) channel (ENaC) in this syndrome. We characterized high fat-fed mice as a model in which to study the contribution of ENaC-mediated Na(+) reabsorption in obesity and… CONTINUE READING
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