Na+ entry via TRPC6 causes Ca2+ entry via NCX reversal in ATP stimulated smooth muscle cells.

@article{Lemos2007NaEV,
  title={Na+ entry via TRPC6 causes Ca2+ entry via NCX reversal in ATP stimulated smooth muscle cells.},
  author={Virg{\'i}nia Soares Lemos and Damon Poburko and Chiu-Hsiang Liao and William C. Cole and Cornelis van Breemen},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={352 1},
  pages={130-4}
}
Reversal of the Na+/Ca2+ -exchanger (NCX) has been shown to mediate Ca2+ influx during activation of G-protein linked receptors. Functional coupling between the reverse-mode NCX and the canonical transient receptor potential channels (TRPCs) has been proposed to mediate Ca2+ influx in HEK-293 cells overexpressing TRPC3. In this communication we present evidence for similar functional coupling of NCX to endogenously expressed TRPC6 in rat aorta smooth muscle cells. Selective inhibition of… CONTINUE READING

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