Na+-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium.

@article{Huda2001NadrivenME,
  title={Na+-driven multidrug efflux pump VcmA from Vibrio cholerae non-O1, a non-halophilic bacterium.},
  author={Md Nazmul Huda and Y{\^u}ji Morita and Teruo Kuroda and Tohru Mizushima and Tomofusa Tsuchiya},
  journal={FEMS microbiology letters},
  year={2001},
  volume={203 2},
  pages={
          235-9
        }
}
A chromosomal DNA fragment from Vibrio cholerae non-O1 containing a drug resistance determinant was cloned and sequenced. The deduced amino acid sequence suggested that the determinant gene encodes a multidrug efflux pump. We designated the pump VcmA. Escherichia coli cells transformed with a plasmid carrying the vcmA gene showed increased resistance against norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium bromide, 4',6-diamidino-2-phenylindole… CONTINUE READING

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