Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier.

  title={Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier.},
  author={Robyn L. O'Kane and Richard Albert Hawkins},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={285 6},
Several Na+-dependent carriers of amino acids exist on the abluminal membrane of the blood-brain barrier (BBB). These Na+-dependent carriers are in a position to transfer amino acids from the extracellular fluid of brain to the endothelial cells and thence to the circulation. To date, carriers have been found that may remove nonessential, nitrogen-rich, or acidic (excitatory) amino acids, all of which may be detrimental to brain function. We describe here Na+-dependent transport of large… 

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