Na+-dependent release of intracellular Ca2+ induced by purinoceptors in parotid acinar cells of the rat.

@article{Fukushi1997NadependentRO,
  title={Na+-dependent release of intracellular Ca2+ induced by purinoceptors in parotid acinar cells of the rat.},
  author={Yasue Fukushi and Terutaka Ozawa and Takahiro Kanno and Makoto Wakui},
  journal={European journal of pharmacology},
  year={1997},
  volume={336 1},
  pages={
          89-97
        }
}
In rat parotid acinar cells, ATP caused a transient increase in the intracellular Ca2+ concentration ([Ca2+]i) in the absence of external Ca2+. The ATP-induced Ca2+ response was strongly suppressed by removal of external Na+. The sequence of potency in increasing [Ca2+]i was 3'-o-(4-benzoyl) benzoyl-ATP > ATP > uridine 5'-triphosphate (UTP). Adenosine, AMP, ADP or alpha,beta-metylene ATP did not cause an increase in [Ca2+]i. The 3'-o-(4-benzoyl) benzoyl-ATP-induced increase in [Ca2+]i was… CONTINUE READING

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