Na+ currents near and away from endplates on human fast and slow twitch muscle fibers.

@article{Ruff1993NaCN,
  title={Na+ currents near and away from endplates on human fast and slow twitch muscle fibers.},
  author={Robert L. Ruff and Dennis J Whittlesey},
  journal={Muscle & nerve},
  year={1993},
  volume={16 9},
  pages={
          922-9
        }
}
Fast and slow twitch muscle fibers have distinct contractile properties. Here we determined that membrane excitability also varies with fiber type. Na+ currents (INa) were studied with the loose-patch voltage clamp technique on 29 histochemically classified human intercostal skeletal muscle fibers at the endplate border and > 200 microns from the endplate (extrajunctional). Fast and slow twitch fibers showed slow inactivation of endplate border and extrajunctional INa and had increased INa at… CONTINUE READING

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