Na+ current densities and voltage dependence in human intercostal muscle fibres.

@article{Ruff1992NaCD,
  title={Na+ current densities and voltage dependence in human intercostal muscle fibres.},
  author={Robert Louis Ruff and D Whittlesey},
  journal={The Journal of physiology},
  year={1992},
  volume={458},
  pages={85-97}
}
1. Voltage-clamp Na+ currents (INa) were studied in human intercostal muscle fibres using the loose-patch-clamp technique. 2. The fibres could be divided into two groups based upon the properties of INa. The two groups of fibres were called type 1 and type 2. 3. Both type 1 and type 2 fibres demonstrated fast and slow inactivation of INa. 4. Type 1 fibres had lower INa on the endplate border and extrajunctional membrane than type 2 fibres and required larger membrane depolarizations to… CONTINUE READING

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