Na+ channel distribution and electrophysiological heterogeneities in guinea pig ventricular wall.

@article{Osadchii2011NaCD,
  title={Na+ channel distribution and electrophysiological heterogeneities in guinea pig ventricular wall.},
  author={Oleg E Osadchii and Ewa Soltysinska and Soren Peter Olesen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 3},
  pages={H989-1002}
}
We sought to explore the distribution pattern of Na(+) channels across ventricular wall, and to determine its functional correlates, in the guinea pig heart. Voltage-dependent Na(+) channel (Na(v)) protein expression levels were measured in transmural samples of ventricular tissue by Western blotting. Isolated, perfused heart preparations were used to record monophasic action potentials and volume-conducted ECG, and to measure effective refractory periods (ERPs) and pacing thresholds, in order… CONTINUE READING

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