Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus.

@article{Devor1989NaCA,
  title={Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus.},
  author={Marshall Devor and C. H. Keller and Thomas J. Deerinck and S. Rock Levinson and Mark H. Ellisman},
  journal={Neuroscience letters},
  year={1989},
  volume={102 2-3},
  pages={149-54}
}
In mammals, cut sensory axons trapped in a nerve end neuroma have been shown to develop hyperexcitability, and to become a source of ectopic afferent discharge and abnormal sensation. We have explored cellular mechanisms underlying neuroma electrogenesis. First we confirmed that ectopic neuroma discharge develops in injured afferents in the electrosensory lateral line nerve of the weakly electric fish Apteronotus, as it does in mammals. Then, using previously characterized antibodies that… CONTINUE READING