Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism

  title={Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism},
  author={Jin Sui and Kim W. Chan and Diomedes E. Logothetis},
  journal={The Journal of General Physiology},
  pages={381 - 391}
Muscarinic potassium channels (KACh) are composed of two subunits, GIRK1 and GIRK4 (or CIR), and are directly gated by G proteins. We have identified a novel gating mechanism of KACh, independent of G-protein activation. This mechanism involved functional modification of KACh which required hydrolysis of physiological levels of intracellular ATP and was manifested by an increase in the channel mean open time. The ATP-modified channels could in turn be gated by intracellular Na+, starting at… CONTINUE READING


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