Na+ H+ exchanger-1: a link with atherogenesis?

  title={Na+ H+ exchanger-1: a link with atherogenesis?},
  author={Maria Sarigianni and Apostolos Tsapas and Dimitri P. Mikhailidis and Martha Kaloyianni and George Koliakos and Larry Fliegel and Konstantinos Paletas},
  journal={Expert opinion on investigational drugs},
  volume={19 12},
IMPORTANCE OF THE FIELD The sodium/hydrogen exchanger-1 (NHE-1/SLC9A1) is a ubiquitous plasma membrane protein whose main role is maintenance of intracellular pH and volume. NHE-1 plays a role in atherogenesis; however, its clinical relevance has not yet been established. AREAS COVERED IN THIS REVIEW We herein review the contribution of NHE-1 in atherogenesis (namely its effect on endothelial cells, monocytes, smooth muscle cells and platelets). WHAT THE READER WILL GAIN Studies have shown… CONTINUE READING