Na+-H+ exchange activity in rat hepatocytes: role in regulation of intracellular pH.

@article{Renner1989NaHEA,
  title={Na+-H+ exchange activity in rat hepatocytes: role in regulation of intracellular pH.},
  author={Eberhard Ludwig Renner and J. Ronald Lake and M. Persico and Bruce F. Scharschmidt},
  journal={The American journal of physiology},
  year={1989},
  volume={256 1 Pt 1},
  pages={G44-52}
}
Amiloride-sensitive Na+-H+ exchange has been identified in basolateral membrane vesicles from rat liver, but little is currently known about its regulation or its role in maintenance of resting intracellular pH (pHi) in intact hepatocytes. We have assessed Na+-H+ exchange activity in isolated or cultured rat hepatocytes in nominally HCO3- free solution under basal conditions and after intracellular acidification by an NH4Cl pulse by measuring 1) pHi, using the pH-sensitive dye 2',7'-bis… CONTINUE READING

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