Na+ Channel β Subunits: Overachievers of the Ion Channel Family

  title={Na+ Channel β Subunits: Overachievers of the Ion Channel Family},
  author={William J Brackenbury and Lori L Isom},
  booktitle={Front. Pharmacol.},
Voltage-gated Na(+) channels (VGSCs) in mammals contain a pore-forming α subunit and one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and β4, encoded by four genes: SCN1B-SCN4B. With the exception of the SCN1B splice variant, β1B, the β subunits are type I topology transmembrane proteins. In contrast, β1B lacks a transmembrane domain and is a secreted protein. A growing body of work shows that VGSC β subunits are multifunctional. While they do not form the… CONTINUE READING
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