Na+-Ca2+ exchange is affected by membrane potential in cardiac sarcolemmal vesicles.

@article{Philipson1980NaCa2EI,
  title={Na+-Ca2+ exchange is affected by membrane potential in cardiac sarcolemmal vesicles.},
  author={Kenneth D. Philipson and Angie Nishimoto},
  journal={The Journal of biological chemistry},
  year={1980},
  volume={255 14},
  pages={6880-2}
}
The effect of membrane potential on the Na+-Ca2+ exchange activity of isolated sarcolemmal vesicles from dog ventricles is examined. Na+-Ca2+ exchange is monitored as Nai+-dependent Ca2+ uptake as described by Reeves and Sutko ((1979) Proc. Natl. Acad. Sci. U. S. A. 76,590-594). Membrane potential is controlled by varying internal and external K+ in the presence of valinomycin. Inside-positive potentials stimulate Nai+-dependent Ca2+ influx. This stimulation is independent of Ca2+ concentration… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…