Na+—Ca2+ Exchange Currents in Cortical Neurons: Concomitant Forward and Reverse Operation and Effect of Glutamate

@article{Yu1997NaCa2EC,
  title={Na+—Ca2+ Exchange Currents in Cortical Neurons: Concomitant Forward and Reverse Operation and Effect of Glutamate},
  author={Shan Ping Yu and Dennis W. Choi},
  journal={European Journal of Neuroscience},
  year={1997},
  volume={9}
}
Na+‐Ca2+ exchanger‐associated membrane currents were studied in cultured murine neocortical neurons, using whole‐cell recording combined with intracellular perfusion. A net inward current specifically associated with forward (Na+o‐Ca2+i) exchange was evoked at ‐40 mV by switching external 140 mM Li+ to 140 mM Na+. The voltage dependence of this current was consistent with that predicted for 3Na+:1Ca2+ exchange. As expected, the current depended on internal Ca2+, and could be blocked by… 
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