Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms.

@article{PrezGmez2010NaKATPaseIP,
  title={Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms.},
  author={Anabel P{\'e}rez-G{\'o}mez and Antonello Novelli and Mar{\'i}a Teresa Fern{\'a}ndez-S{\'a}nchez},
  journal={Journal of neurochemistry},
  year={2010},
  volume={114 1},
  pages={28-38}
}
Dysfunction or deficiency of the Na(+)/K(+)-ATPase appears to be a common event in a variety of pathological conditions in the central nervous system. Studies on neurotoxicity associated to impaired Na(+)/K(+)-ATPase activity have focused on NMDA receptors, while the involvement of non-NMDA receptors has been much less explored. We show that mild, non-toxic, exposures to the Na(+)/K(+)-ATPase inhibitor palytoxin (PTX) synergistically sensitized the vulnerability of neurons to normally non-toxic… CONTINUE READING

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Studies on neurotoxicity associated to impaired Na(+)/K(+)-ATPase activity have focused on NMDA receptors , while the involvement of non - NMDA receptors has been much less explored .
Studies on neurotoxicity associated to impaired Na(+)/K(+)-ATPase activity have focused on NMDA receptors , while the involvement of non - NMDA receptors has been much less explored .
Studies on neurotoxicity associated to impaired Na(+)/K(+)-ATPase activity have focused on NMDA receptors , while the involvement of non - NMDA receptors has been much less explored .
Studies on neurotoxicity associated to impaired Na(+)/K(+)-ATPase activity have focused on NMDA receptors , while the involvement of non - NMDA receptors has been much less explored .
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