Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells.

@article{Steffan2009NaHEA,
  title={Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells.},
  author={Joshua James Steffan and Jared Lee Snider and Omar Skalli and Tomas C. Welbourne and James A. Cardelli},
  journal={Traffic},
  year={2009},
  volume={10 6},
  pages={
          737-53
        }
}
Acidic extracellular pH (pHe) is a common feature of the tumor microenvironment and has been implicated in tumor invasion through the induction of protease secretion.Since lysosomes constitute the major storehouse of cellular proteases, the trafficking of lysosomes to the cell periphery may be required in order to secrete proteases. We demonstrate that a pHe of 6.4-6.8 induced the trafficking of lysosomes to membrane protrusions in the cell periphery. This trafficking event depended upon the… CONTINUE READING
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