Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis.

@article{Liu2012NaHER,
  title={Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis.},
  author={Li Liu and V Mar{\'i}a Josefina Alonso and Lida Guo and Irina L. Tourkova and Sarah Elizabeth Henderson and Alejandro J. Almarza and Peter A Friedman and Dr. Harry C. Blair},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 52},
  pages={
          43312-21
        }
}
Bone formation requires synthesis, secretion, and mineralization of matrix. Deficiencies in these processes produce bone defects. The absence of the PDZ domain protein Na(+)/H(+) exchange regulatory factor 1 (NHERF1) in mice, or its mutation in humans, causes osteomalacia believed to reflect renal phosphate wasting. We show that NHERF1 is expressed by mineralizing osteoblasts and organizes Na(+)/H(+) exchangers (NHEs) and the PTH receptor. NHERF1-null mice display reduced bone formation and… CONTINUE READING
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