Na+/H+-exchanger 3 activity and its gene in the spontaneously hypertensive rat kidney.

@article{Hayashi1997NaHexchanger3A,
  title={Na+/H+-exchanger 3 activity and its gene in the spontaneously hypertensive rat kidney.},
  author={Mutsumi Hayashi and Tadashi Yoshida and Toshiaki Monkawa and Yasufumi Yamaji and Shun Sato and Takao Saruta},
  journal={Journal of hypertension},
  year={1997},
  volume={15 1},
  pages={43-8}
}
OBJECTIVE To examine the mechanisms affecting proximal tubule sodium reabsorption, we studied the gene expression and functional changes of the Na+/H+-exchanger 3 (NHE3) and its gene expression in spontaneously hypertensive rats (SHR). METHODS The S1 segment of the superficial proximal convoluted tubules (PCT) was microdissected from collagenase-treated kidneys of SHR and Wistar-Kyoto (WKY) rats. The tubules were then superfused in a HEPES-buffered solution. The intracellular pH was measured… CONTINUE READING

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