Na+/H+ exchange is increased in sickle cell anemia and young normal red cells

@article{Canessa1990NaHEI,
  title={Na+/H+ exchange is increased in sickle cell anemia and young normal red cells},
  author={M Aurora Canessa and Mary E. Fabry and Sandra M. Suzuka and Kevin A Morgan and Ronald L. Nagel},
  journal={The Journal of Membrane Biology},
  year={1990},
  volume={116},
  pages={107-115}
}
Red cell volume regulation is important in sickle cell anemia because the rate and extent of HbS polymerization are strongly dependent on initial hemoglobin concentration. We have demonstrated that volume-sensitive K:Cl cotransport is highly active in SS whole blood and is capable of increasing MCHC. We now report that Na+/H+ exchange (Na/H EXC), which is capable of decreasing the MCHC of erythrocytes with pHi<7.2, is also very active in the blood of patients homozygous for HbS. The activity of… CONTINUE READING
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