Na+,K(+)-ATPase in the choroid plexus. Regulation by serotonin/protein kinase C pathway.

@article{Fisone1995NaKATPaseIT,
  title={Na+,K(+)-ATPase in the choroid plexus. Regulation by serotonin/protein kinase C pathway.},
  author={G Fisone and Gretchen L. Snyder and Jessica Fryckstedt and Michael J Caplan and Anita C. Aperia and Paul Greengard},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 6},
  pages={2427-30}
}
In the choroid plexus, the ion pump Na+,K(+)-ATPase regulates the production of cerebrospinal fluid. We now report that incubation of choroid plexus with an activator of protein kinase C, phorbol 12,13-dibutyrate, strongly stimulates the phosphorylation of Na+,K(+)-ATPase and inhibits its activity. Similar effects were obtained with serotonin, which in the choroid plexus stimulates phosphoinositide turnover, thereby activating protein kinase C. Serotonin (10 microM) increased by about 10-fold… CONTINUE READING

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