Na+,K(+)-ATPase expression in maleic-acid-induced Fanconi syndrome in rats.

  title={Na+,K(+)-ATPase expression in maleic-acid-induced Fanconi syndrome in rats.},
  author={Esther Casta{\~n}o and P Marzabal and Fco Javier Casado and Antonio Felipe and Marçal Pastor-Anglada},
  journal={Clinical science},
  volume={92 3},
Na+,K(+)-ATPase activity and its alpha 1 subunit protein and mRNA in kidney cortex were monitored in rats developing Fanconi syndrome after the administration of maleate. Na+,K(+)-ATPase activity was significantly lower than in saline-injected controls, although this was partially mediated by a general, non-specific decrease in the cortex protein content. 2. The low activity of the sodium pump correlated with low abundance of alpha 1 subunit mRNA and protein levels. Hsp60 protein levels were… CONTINUE READING
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