Na+, K(+)-pump activity and skeletal muscle contractile deficits in the spontaneously hypertensive rat.

@article{Carlsen1996NaKA,
  title={Na+, K(+)-pump activity and skeletal muscle contractile deficits in the spontaneously hypertensive rat.},
  author={Richard C. Carlsen and Sarah D. Gray and Joel G. Pickar},
  journal={Acta physiologica Scandinavica},
  year={1996},
  volume={156 3},
  pages={237-45}
}
Skeletal muscles in an animal model of genetic hypertension (the spontaneously hypertensive rat. SHR) exhibit significant deficits in contractile performance. These deficits appear to be unrelated to the rise in blood pressure. Slow-twitch soleus muscles show a decrease in specific muscle tension and a reduced resistance to muscle fatigue during prolonged contractile activity. We tested the hypothesis that the reduced fatigue resistance occurs as a consequence of an impaired ability to maintain… CONTINUE READING