Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils

@article{DeCoursey1994NaHAD,
  title={Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils},
  author={Thomas E DeCoursey and Vladimir Cherny},
  journal={The Journal of General Physiology},
  year={1994},
  volume={103},
  pages={755 - 785}
}
Voltage-activated H(+)-selective currents were studied in cultured adult rat alveolar epithelial cells and in human neutrophils using the whole-cell configuration of the patch-clamp technique. The H+ conductance, gH, although highly selective for protons, was modulated by monovalent cations. In Na+ and to a smaller extent in Li+ solutions, H+ currents were depressed substantially and the voltage dependence of activation of the gH shifted to more positive potentials, when compared with the… CONTINUE READING

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