Na(+)-Ca2+ exchange function underlying contraction frequency inotropy in the cat myocardium.

@article{Petroff2003NaCa2EF,
  title={Na(+)-Ca2+ exchange function underlying contraction frequency inotropy in the cat myocardium.},
  author={Martin Vila Petroff and Julieta Palomeque and Alicia R. Mattiazzi},
  journal={The Journal of physiology},
  year={2003},
  volume={550 Pt 3},
  pages={801-17}
}
In most mammalian species, an increase in stimulation frequency (ISF) produces an increase in contractility (treppe phenomenon), which results from larger Ca2+ transients at higher frequencies, due to an increase in sarcoplasmic reticulum Ca2+ load and release. The present study attempts to elucidate the contribution of the Na(+)-Ca2+ exchanger (NCX) to this phenomenon. Isolated cat ventricular myocytes, loaded with [Ca2+]i- and [Na+]i-sensitive probes, were used to determine whether the… CONTINUE READING

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