Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues.

  title={Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues.},
  author={Ludovic Lacroix and Caterina Mian and Bernard Caillou and Monique Talbot and Sebastiano Filetti and Martin Schlumberger and Jm. Bidart},
  journal={European journal of endocrinology},
  volume={144 3},
OBJECTIVE The expression of two recently identified iodide transporters, namely the sodium/iodide symporter (NIS) and pendrin, the product of the gene responsible for the Pendred syndrome (PDS), was studied in a series of various extra-thyroidal human tissues, and especially in those known to concentrate iodide. METHODS To this end, we used real-time kinetic quantitative PCR to detect NIS and PDS transcripts and immunohistochemistry for the analysis of their protein products. RESULTS NIS… CONTINUE READING
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