Na(+)/Ca(2+) exchanger expression and function in a rabbit model of myocardial infarction.

INTRODUCTION In general, sarcolemmal Na(+)/Ca(2+) exchanger (NCX) protein and activity is increased in hearts with ventricular dysfunction. However, in a subset of studies, reduced activity of NCX has been reported. Left ventricular dysfunction (LVD) was induced in the rabbit eight weeks after an apical myocardial infarction. METHODS Using single… CONTINUE READING