NY-ESO-1 specific TCR engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma

@inproceedings{Rapoport2015NYESO1ST,
  title={NY-ESO-1 specific TCR engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma},
  author={Aaron P. Rapoport and Edward A. Stadtmauer and Gwendolyn K. Binder-Scholl and Olga G. Goloubeva and Dan T Vogl and Simon F Lacey and Ashraf Z Badros and Alfred L Garfall and Brendan M Weiss and Jeffrey Finklestein and Irina M Kulikovskaya and Sudhir Kumar Sinha and Shari S. Kronsberg and Minnal Gupta and Sarah Bond and Luca Melchiori and Joanna E. Brewer and Alan David Bennett and Andrew B. Gerry and Nicholas J. Pumphrey and Daniel J. L. Williams and Helen K. Tayton-Martin and Lilliam Ribeiro and Tom Holdich and Saul Yanovich and Nancy T. Hardy and Jean A Yared and Naseem D. S. Kerr and S Hartman Philip and Sandra Westphal and Donald L. Siegel and Bruce L Levine and Bent Karsten Jakobsen and Michael D. Kalos and Carl H June},
  booktitle={Nature Medicine},
  year={2015}
}
Despite recent therapeutic advances, multiple myeloma (MM) remains largely incurable. Here we report results of a phase I/II trial to evaluate the safety and activity of autologous T cells engineered to express an affinity-enhanced T cell receptor (TCR) recognizing a naturally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1. Twenty patients with antigen-positive MM received an average 2.4 × 109 engineered T cells 2 d after autologous stem cell transplant. Infusions… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 168 CITATIONS, ESTIMATED 47% COVERAGE

Current Status of Gene Engineering Cell Therapeutics

VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cell-based immunotherapy approaches for multiple myeloma

  • British Journal of Cancer
  • 2018
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Adoptive Cellular Therapy (ACT) for Cancer Treatment.

  • Advances in experimental medicine and biology
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Development of Novel Immunotherapies for Multiple Myeloma

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Retroviral Vectors for Cancer Gene Therapy.

  • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2016
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2015
2019

CITATION STATISTICS

  • 12 Highly Influenced Citations

  • Averaged 41 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

American Society of Clinical Oncology

Merchant, S Melinda, +10 authors Crystal. Mackall
  • Illinois; Chicago:
  • 2015

Current concepts in the diagnosis and management of cytokine release syndrome

DW Lee
  • 2014

T-cell immunotherapy: looking forward.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2014

Similar Papers

Loading similar papers…