NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment

@inproceedings{Redjimi2011NYESO1SpecificCC,
  title={NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment},
  author={Nassima Redjimi and Karine Duperrier-Amouriaux and Isabelle Raimbaud and Immanuel F. Luescher and Danijel Doj{\vc}inovi{\'c} and J. Classe and Dominique Berton-Rigaud and Jean-S{\'e}bastien Fr{\'e}nel and Emmanuelle Bourbouloux and Danila Valmori and Maha Ayyoub},
  booktitle={PloS one},
  year={2011}
}
Spontaneous CD4(+) T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4… CONTINUE READING
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