NY-ESO-1 DNA vaccine induces T-cell responses that are suppressed by regulatory T cells.

  title={NY-ESO-1 DNA vaccine induces T-cell responses that are suppressed by regulatory T cells.},
  author={Sacha Gnjatic and Nasser Khaled Altorki and Derek Ng Tang and Shi-ming Tu and Vikas Kundra and Gerd Ritter and Lloyd J. Old and Christopher J. Logothetis and P Sharma},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 6},
PURPOSE Different vaccination strategies against the NY-ESO-1 antigen have been employed in an attempt to induce antitumor immune responses. Antigen-specific effector T-cell responses have been reported in a subset of vaccinated patients; however, these responses have not consistently correlated with disease regression. Here, we report for the first time clinical and immune responses generated by the NY-ESO-1 DNA vaccine administered by particle-mediated epidermal delivery to cancer patients… CONTINUE READING


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